Our culture has changed tremendously over the last few hundred years. Our life expectancy, literacy, access to different foods, access to different places, how much information we have and the way we process it, the technology that supports us, what we know about the world and how we interact with it.
What have these differences done to us, genetically, physically, mentally, emotionally? How have we changed?
Related questions: What is time? How have we changed the world? How much does our past determine our future?